Quantitative mass spectrometry in diagnostics of influenza and control of action of the medicinal product "Triazavirine"

To improve the methods for diagnosing and treating influenza, we performed quantitative mass spectrometric studies of the activity of two main carboxypeptidases — angiotensin-converting enzyme and carboxypeptidase-N. The comparison of activity levels of these peptidases was carried out for mice both healthy and influenza A/Aichi/2/68 (H3N2) virus infected, as well as for treated with the experimental triazavirin anti-influenza drug. An analysis similar to the fulfilled in this work can be successfully used in a comparative assessment of the effectiveness of other anti-influenza drugs, as well as to understand the direction of their effect on the infected organism.