Quantitative lc-ms/ ms determination of valsartan and hydrochlorothiazide in human plasma

Development and validation of the highly selective and sensitive LC-MS/MS method to detect valsartan and hydrochlorothiazide in human plasma were performed. Mass spectrometriy detection made it possible to enhance analytical performance without time- and labor consuming sample preparation procedures, thus improving the overall bioanalytical productivity in the course of the bioequivalence study.