Comorbid pathology and mechanisms of development of atherosclerosis with in-stent restenosis in ischemic heart disease after percutaneous transluminal coronary angioplasty (review)

In-stent restenosis (ISR) is the most unfavorable complication of interventional treatment of coronary heart disease. The main pathogenetic mechanisms of this complication are neointimal hyperplasia and neoatherosclerosis. Concomitant pathology can provoke the mentioned processes increasing the probability of restenosis formation. Objective: comprehensive coverage of the main issues of comorbidity influence on the risk of coronary artery restenosis after percutaneous transluminal coronary angioplasty. Literature search was performed in PubMed, Google Scholar, Scopus, Web of Science, eLibrary, including original studies in the period from 2006 to 2021. A total of 37849 articles were initially found in the above databases by the fact of keyword mention; 32 most significant papers were included in the review as a result of using the exclusion criteria. The influence of obesity, diabetes mellitus on the risk of ISR was demonstrated.