Comorbidity of affective disorders and metabolic syndrome among adult population of Krasnoyarsk

The purpose of this study was to assess relationships between metabolic syndrome (MS) and depressive disorders (DD) among adult population in Krasnoyarsk taking into account gender identity. Materials and Methods. We analyzed data of 1123 subjects aged 25-34 years who participated in the study titled “Epidemiology of Cardio-Vascular Diseases in Russian Federation - 2012”. We studied the levels of depression according to hospital anxiety and depression scale (HADS); indicators of metabolic syndrome (MS) were assessed according to the criteria of Adult Treatment Panel III (ATP III); the relationships between depressive disorders and MS were evaluated. Results. The frequency of MS among adult population of Krasnoyarsk was 23% (20.5% among men and 24.4% among women). Men with and without MS equally often had subclinical depression and clinical depression (15.5% vs. 13.3% for subclinical depression and 3.6% vs. 4.0% for clinical depression). In women with MS, depressive disorders were diagnosed significantly more often in comparison with women without MS (23.3% vs. 16.3% for higher level of depression, p=0.038 and 7.6% vs 3.7% for clinical depression, p=0.039). In addition, among women with components of MS such as abdominal obesity (AO) and increased blood pressure (IBP), the prevalence of subclinical depression was significantly higher in comparison with women without AO and IBP. Conclusions. General practitioners should give special attention to women with MS, since depressive disorders are more common in this group of patients. In women, such MS components as AO and IBP are associated with depressive disorders. Timely diagnosis of depressive disorders among women with MS can have a positive impact on adherence to MS therapy, thereby reducing overall cardiovascular risk.