Complex treatment of patients with chronic abacterial prostatitis using hypercapnic hypoxia

Aim. To evaluate the effectiveness of the impact of hypercapnic hypoxia on prostate microcirculation in patients with chronic abacterial prostatitis (CAP). Materials and methods. For the evaluation of the impact of hypercapnic hypoxia on prostate blood flow in patients with CAP, we examined 39 male patients aged 20-50 and divided them into two groups. The first group consisted of 18 patients (46%), who were receiving only basal therapy comprising daily administration of one pill oflevofloxacin (Tavanic), one capsule oftamsulosin (Omnic), one capsule of Serenoa repens extract (Prostamol Uno), one sachet of nimesulide (Nimesil) 1-2 timer per day and rectal administration of one suppository of Samprost. The basal therapy was prescribed according to clinical recommendations developed by the Russian Urological Society and the Association of Medical Societies for Quality. The second group consisted of 21 patients (54%), whose treatment, apart from the basal therapy, included respiratory exercises with the effect of hypercapnic hypoxia (10 sessions during the course). Such exercises lead to the increase in the partial pressure of carbon dioxide and to the decrease in the partial pressure of oxygen and therefore affect organ microcirculation. In order to examine the blood flow in the prostate, we used the data from laser Doppler flowmetry obtained using the laser analyzer LAKK-02. This diagnostic technique, aimed at detecting various microcirculatory defects, is more accurate, sensitive and enables longer time of exposure. Results. After the course of treatment, we revealed the improvement of arterial blood flow in the prostate, elevation of blood perfusion and arteriolar flow and the boost of prostate microcirculation. We also noticed the decrease of hypoxia and ischaemization of prostate tissues and the presence of active mechanism of blood flow regulation in the prostate. Conclusion. Hypercapnic hypoxia largely contributes to prostate microcirculation, which indicates its effectiveness for treating CAP