Composition of hepatoprotective extracts and its stress-protective effects in a mouse experiment

This study investigated the effects of a number of biologically active substances on stressinduced reactions of the organism, the trigger for which was thermal exposure. The relevance of this study is explained by the prospective application of various biologically active additives. Stress factor was formed by placing the control and experimental groups of mice in a dry heat oven for 1 min, with a temperature of 55 ºC, in the regime of 5 days of experience, 2 days of pause. The control group consisted of 20 non-pregnant female white nonlinear mice weighing 110-180 g. The experimental group consisted of 20 female white nonlinear mice. In total, four groups of mice were taken: Control group (N=20) – received xenobiotic; Silybum marianum group 50-249.7 mg/kg (N=7); Angelica keiskei koidzumi group 50-249.7 mg/kg (N=6); Composition group 50-249.7 mg/kg (Silybum marianum+Angelica keiskei koidzumi) (N=7). Significant differences between the groups of animals receiving monotherapy or the composition indicate the presence of mutual enhancement (synergistic effect) of stress-protective activity of the components included in the composition.