Criteria for the assessment of the state of immunological indicators in connection with immunization of vascular tissue homoantigen

On the experimental model of autoimmune vascular lesions, immunological shifts have been studied by posing a number of simple, convenient, effective methods for analyzing immune shifts arising from the introduction of a homologous vascular antigen to experimental animals. Numerous clinical and experimental studies have shown the importance of autoimmune changes in the pathogenesis of a number of diseases of internal organs. However, the issue of the role of immunological reactivity in the development of vascular pathology (athero-arteriosclerosis) has not been sufficiently studied, despite the fact that there are a considerable number of works on this issue indicating the presence of an autoimmune reaction to vascular tissues in arteriosclerosis. The study of immunological changes in the development of vascular lesions caused by their damage by homologous tissue antigens is relevant. At the same time, however, it is necessary to take into account the peculiarities of organ-specific antigens, their isolation in the body and the absence of their access and circulation, which also makes it possible to autosensitize. This circumstance undoubtedly has an important practical significance in modeling organ pathology, since it allows one to deepen the understanding of the pathophysiological mechanisms in each specific case.