Laser photochemical debridement in the treatment of local infection of soft tissues and bones

Introduction. Combined infectious defects of bone and soft tissues represent one of the most difficult problems of modern clinical practice. Despite the development of innovative strategies, understanding of the pathogenesis and mechanisms of antibiotic resistance, the effectiveness of their treatment remains unsatisfactory. The use of low-intensity laser radiation is considered as a promising direction in the local treatment of soft tissue and bone infections. The purpose of the study. To substantiate the tactics of choosing a photosensitizer for laser photochemical debridement (LPD) for the treatment of soft tissue and bone infections. Materials and methods. The analysis of scientific literature presented on PubMed, eLibrary, MEDLINE, ScienceDirect is carried out. The study is planned to include data from 2015–2025. However, due to insufficient information, it was decided to expand the study to include data from 2005–2025. Results. LPD is highly effective in the complex treatment of soft tissue and bone infections. The effect on biofilms and bacterial metabolism makes this method especially relevant for persistent forms of chronic infection. The tactics of choosing FS for photochemical exposure includes several stages: assessment of the patient's contraindications to the use of FS; identification of the pathogen in the focus of infection; selection of a laser radiation source with the required wavelength. Conclusion. Thus, the use of LPD is an effective method of combating infection of soft tissues and bones. The use of LPD makes it possible to shorten the duration of treatment, reduce relapses and improve the quality of life of patients.