The treatment of gastroesophageal reflux in patients after sleeve gastrectomy in the nearest postoperative period

Purpose of the study is to evaluate the effectiveness of treatment of gastroesophageal reflux disease in patients after sleeve gastrectomy using botulinum toxin injections into the pylorus.Materials and research methods. A prospective controlled study of 42 patients undergoing laparoscopic sleeve gastrectomy with a postoperative period of one to six months. The patients were divided into two groups: the main group (21 patients) underwent complex treatment, including basic conservative therapy, supplemented by endoscopic injection of botulinum toxin into the pylorus; the comparison group (23 patients) received only basic conservative therapy. All patients included in the study were questioned using the GERD-HRQL questionnaire.Research results. In the main group, one month after the botulinum toxin injection, the overall score according to the GERD-HRQL questionnaire reliably reflected the positive dynamics in the course of gastroesophageal reflux disease. Six months after the start of treatment in the main group, the average score was significantly lower than in the comparison group (p ⊞ 0,05), and the general satisfaction of patients with respect to control over symptoms of gastroesophageal reflux was 85% (satisfactory + neutral). In the comparison group, after 6 months, there was no significant and reliable dynamics, and the general dissatisfaction with the state remained at the level of 65%.Conclusion. Basic conservative therapy in combination with the procedure of endoscopic injection of botulinum toxin into the pylorus effectively helps to reduce the clinical manifestations of gastroesophageal reflux in the immediate postoperative period after sleeve gastrectomy.