Lipid fraction from brown seaweed Saccharina japonica as pharmacological remedy at hepatosis

It was shown, that lipids fraction separated from water-ethanol extract (70%) of brown kelp thallome Sacharina japonica ( Saccharina japonica (Miyabe)), containing combination of neutral and phospholipids with high content of polyunsaturated fatty acids of n-3 and n-6 family, possess hepatoprotective activity at CCL4-induced liver damage in Wistar rats. It was registered the restoration of the specific liver weight and its esterifying function, reducing of alaninaminotransferase activity in blood and malone dialdehyde level in liver, diminution of fatty infiltration because of decreasing of general lipids and restoration of phospholipids pattern of hepatocyte membranes. It was shown that lipid complex from Sacharina japonica facilitates normalization of liver lipid metabolism indexes more effective, than reference hepatoprotector “Essentiale ®. Sacharina japonica is a promising raw material for obtaining of hepatoprotectors containing essential phosopholipids.