The localization of indole-containing substances in bone marrow structures after heterografting

The localization of indole-containing substances and their impact on bone marrow structure was studied. Experiments were carried out on male mice which were intravenously injected with bone marrow taken from guinea pigs. Using the Masson-Fountains method in the early stages after heterografting it was observed that there was an increase in indole-containing substances content in mast, granule cells, in erythroid cells and megakaryocytes. By the end of the experiment mast and granule cells were not identified; these substances were detected in a few isolated granules. Formation of adipose cells, which were intensively impregnated by indole-containing substances took place. Replacement of bone marrow structures by lipocytes was observed. Processes of cells proliferation in the bone marrow were interrupted.