The magnetic effect of antibacterialeffects of radition benzylpenicillin sodium salt

Currently, the problem of bacterial resistance to antibiotics is becoming increasingly important. There are two solutions to this problem: the creation of new classes of antibiotics or an increase in their antibacterial activity, for example, under the physical influence of a magnetic field. In addition, there is a scientific interest - to reveal the mechanism of this effect on the substance, to assess its accompanying while kinetic effects. Widely used β-lactam antibiotics (penicillins, cephalosporins, etc.), A common moiety in their structure a β-lactam ring, which is associated with the presence of microbiological activity of these drugs and with it bind specific enzymes (penicillin binding proteins). Data antibiotic activity is determined by their affinity to penicillin-binding proteins. In this article it has been found gain antibacterial effects benzylpenicillin sodium salt powder is irradiated with a pulsed magnetic field under certain of its parameters: intensity H, the frequency f, the number of pulses n. Pulsed magnetic field was carried out as in powdered benzylpenicillin sodium, and the antibiotic in solution. We studied the effect of storage time of the irradiated powder penicillin to change the diameters of the zones of growth suppression object of the study were bacteria E. coli. Evaluation of the antibacterial effect was carried out to increase the lysis zones E. coli as compared to a control (not of irradiated) pictures. A model of (explanation) of the behavior of the antibiotic molecule under the influence of UTI. It is hypothesized increase the antibacterial activity of penicillin sodium salt under the influence of UTI associated with a change in the conformation of the penicillin molecule.