Cu/Fe magnetic nanoparticles with antitumor activity

Автор: Olga V. bakina, Elena A. glazkova, Natalia V. svarovskaya, Matvey S. korovin, Alla N. fomenko, Marat I. lerner, Alexandra V. avgustinovich

Журнал: Сибирский онкологический журнал @siboncoj

Рубрика: Лабораторные и экспериментальные исследования

Статья в выпуске: 1 т.17, 2018 года.

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The use of bimetallic nanoparticles of biocompatible metals with magnetic properties is a new approach to combating cancer cells. Nanoparticles of immiscible Fe/Cu metals, with separated phases at the level of one particle, were synthesized by electric explosion of iron and copper wires in an argon atmosphere. To characterize Cu/Fe nanoparticles, X-ray phase analysis, transmission electron microscopy, thermal desorption of nitrogen, and energy-dispersive analysis were used. Our research has shown that synthesized nanoparticles have antitumor activity against Neuro 2A and J 774 cell lines. Such particles may be promising for the development of drugs for magnetic target delivery.

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Magnetic nanoparticles, electric explosion of metal conductors, core-shell structure, segregated structure, MTT test, tumor cells

Короткий адрес: https://sciup.org/140254157

IDR: 140254157   |   DOI: 10.21294/1814-4861-2018-17-1-19-25

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