Osteogenesis markers in peripheral blood as pathogenetic factors and predictors of the systemic effects of implants for osteosynthesis

The aim of the complex study was to search informative laboratory indices for assessment and prediction of the systemic changes in bone tissue for osteosynthesis of long tubular bones using titanium plates with calcium phosphate coating for fixation. Biochemical markers of bone metabolism (osteocalcin, CrossLaps, alkaline phosphatase, calcium) and hormonal state (hydrocortisone, somatotrophic hormone) have been studied in peripheral blood of 47 №rmal subjects (22 men, 25 women), patients at the moment of surgical performance of bioinert (13 men, 8 women) or bioactive (31 men, 26 women) osteosynthesis, in the dynamics (1-6 months) of bioinert (21 subjects) or bioactive (51 patients) external fixation of single femoral or tibial fractures. It has been established that implants with calcium phosphate coating have a systemic regulating effect on bone tissue metabolism. The main mechanism of their positive influence on reparative regeneration of bone tissue is associated with the increase of organism's calcium depot. High calcium level in blood serum is the most important predictor of successive external osteosynthesis.