Massive tumor burden in Hodgkin’s lymphoma as a prognostic factor in young adults

The aim of the study was the assessment of tumor burden’s components (a mediastinum/thoracic ratio - MTR, peripheral bulky disease, and number of involved lymph nodes) in young adults with Hodgkin’s lymphoma and the analysis of their predictive value. Data on 87 patients aged from 19 till 29 years (median 24 ± 4 years) are submitted. The optimum cut-off level according ROC method for MTR has been established at 0.33, for peripheral bulky disease has been established at 46 mm, and for number of involved lymph nodes has been established at 5. Use of the correlation and regression analysis allocated the best linear regression model for MTR with the maximum determination coefficient and the minimum residual dispersion. There were statistically significant the equation by Fischer's criterion and determination coefficient (Ffact(46.74)>Ftheor(4.17)). Linear and nonlinear regression models for «a peripheral lymphadenopathy» and «number of involved zones» didn't show significant influence on the outcome (p=0.9237 and p=0.3385, respectively). MTR significant influenced the late results. The disease-free survival in patient’s group with MTR less than 0.33 was 100 %, in group with MTR more than 0.34 was 41 % (log-rank test 0.04649).