Mathematical modeling of the endocrine system

Hormones, having their own unique rhythms of secretion, have a systemic effect on all organs and systems of the human body. Combined mathematical modeling and experimental approaches have shown that these rhythms are the result of regulatory processes occurring at many levels of the body and require constant dynamic balancing, especially in response to stimuli. In a review of the literature, we have shown how such a hybrid approach has been successfully applied to unravel the complex mechanisms of regulation of carbohydrate metabolism (metabolic axis), hypothalamic-pituitary-adrenal and hypothalamic-pituitary-gonadal axes. In addition, the prospects for further development of this direction are shown.