Drug conversion of heart rhythm by amiodarone and niferidile in patients with atrial fibrillation and flutter

In 143 patients underwent drug-induced heart rate conversion. Niferidil was used as a drug for therapy in 50 patients, and amiodarone was used in 93 patients. A comparative analysis was performed to determine the effectiveness and safety of drug conversion of heart rhythm with these drugs in patients with atrial fibrillation and flutter. It was found that to restore sinus rhythm in patients with atrial fibrillation, niferidil is not inferior to amiodarone, and in patients with atrial flutter, it is superior to it, provided that atrial flutter has a tachysystolic variant. Amiodarone was statistically significantly safer in all groups for the development of such adverse complications as: the appearance of bradycardia with a heart rate of less than 50 beats per minute and the lengthening of the period of repolarization of the ventricles of the heart (the QTс interval on the ECG). Significantly more often in patients with atrial fibrillation and fluttering during conversion of heart rhythm with niferidil, ventricular extrasicitols were registered, but they spontaneously regressed in most patients in the first hours after administration of the drug.