Mechanisms of hemopoiesis inhibition and restoration using the doxorubicin/docetaxel regimen in bresat cancer patients

Side effects of doxorubicine/docetaxel regimen with regard to erythroid and granulocytic sprouts of hemopoiesis as well as the processes of their restoration were studied in patients with stage III–IV breast cancer. Intensive maturation of erythroid and granulocytic colony forming units was shown to provide hemopoiesis regeneration even in conditions of reduced proliferative activity of these cells resulting in accumulation of mature erythrokaryocytes and mature and immature neutrophil granulocytes in the bone marrow .