Механизмы врожденного иммунитета. Изучение с использованием мышиной модели

Автор: Полторак Александр Николаевич

Журнал: Ученые записки Петрозаводского государственного университета @uchzap-petrsu

Статья в выпуске: 4 (125), 2012 года.

Бесплатный доступ

Установление и изучение многочисленных функций генов человека является одной из главных задач современной иммуногенетики. Вследствие высокой степени гомологии между мышиным и человеческим геномами важная роль в решении этой задачи принадлежит мышиной модели, использование которой возросло в связи с выведением различных инбредных линий мышей. Различия в иммунном ответе в мышиных линиях были неоднократно использованы для нахождения иммунологически компетентных генов. В данном обзоре приведены некоторые из наиболее успешных и известных примеров использования мышей в изучении врожденного иммунитета.

Врожденный иммунитет, мышиная модель, геном человека, инфекции, воспаление

Короткий адрес: https://sciup.org/14750152

IDR: 14750152

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