Метаболическая регуляция функций натуральных киллеров

Автор: Орлова Екатерина Григорьевна

Журнал: Вестник Пермского университета. Серия: Биология @vestnik-psu-bio

Статья в выпуске: 1, 2023 года.

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Согласно современным представлениям, трансформация фенотипа и функций натуральных киллеров (NK-клеток) ассоциирована с метаболическим репрограммированием, а именно преимущественным использованием клеткой специфических метаболических путей для получения энергии. Ключевыми молекулами, участвующими в контроле метаболических программ NK-клеток, являются мишень для рапамицина в клетках млекопитающих (mTOR) и аденозинмонофосфат-активируемая протеинкиназа (AMPK). Модуляция активности mTOR и AMPK различными агентами определяет метаболическое репрограммирование, изменение фенотипа NK-клеток и функциональной активности. Особенности метаболической регуляции эффекторных функций NK-клеток зависят от их локализации, степени зрелости, продолжительности и специфичности активационных сигналов. Особое внимание уделяется изменению фенотипа, функциональной и метаболической активности NK-клеток при беременности, что ассоциировано с формированием периферической иммунной толерантности. Изучение метаболической регуляции функциональной активности NK-клеток необходимо для повышения эффективности NK-клеточной терапии.

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Nk-клетки, метаболизм, децидуальный фенотип, иммунная толерантность, беременность

Короткий адрес: https://sciup.org/147240457

IDR: 147240457 | DOI: 10.17072/1994-9952-2023-1-83-94

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