Metabolic pulmonary function in case of striatum and substantia nigra dysfunction

The objective of the paper is to study surfactant lipid metabolism, lung water balance, and blood coagulation potential in pulmonary circulation in case of striatum and substantia nigra dysfunction. Materials and Methods. Studies were carried out on male rats: both sham-operated (n=38) and experimental. The authors modeled the focus of a disease in the reticular formation of substantia nigra (n=20) and in striatum (n=15) by stereotactic implantation of cobalt nanopowder which underwent mechanical activation in a ball planetary mill (AGO-2). They also induced and in case of substantia nigra neurodegeneration by unilateral administration of neurotoxin 6-hydroxydopamine into the zona compacta (n=9). Surfactant lipid metabolism was studied taking into consideration phospholipid content in bronchoalveo- lar lavages and their fractional composition which was determined by thin-layer chromatography (TLC) according to phospholipase activity. Gravimetric method was used to evaluate the content of total, extra-vascular lung fluid, and organ blood supply. Standard procedures were applied to determine partial thromboplastine time (PTT) and prothrombin time (PT) of venous and arterial blood using Solar CGL 2110. Arteriovenous ratio was calculated. The content of malondialdehyde in lung tissue was determined to evaluate the intensity of free radicals. Results and Dicussion. It was found out that at substantia nigra dysfunction surfactant metabolism disorders are observed quite often. At striatum dysfunction the development of organ overhydration takes place. It was shown that if substantia nigra neurodegenerates the deterioration of surfactant surface-active characteristics is associated with decrease of phospholipids, phosphatidylcholine and high intensity of phospholipase hydrolysis. Nigral structure activation induces the synthesis of phospholipids by means of lysophosphatidylcholine, sphingomyelin, and phosphatidylethanolamine fractions. The effectiveness of control mechanisms of blood coagulation potential in the pulmonary blood flow is observed at striatum manipulations and damaged at substantia nigra dysfunction. Conclusion. Changes of non-gas-exchanging functions along with violations in lung ventilation mode can lead to dysregulation pneumopathy in case of substantia nigra and striatum dysfunction.