Metabolic markers as prognostic factors for complications of abdominoplasty

Introduction. Performing plastic surgery, in particular, abdominoplasty, is characterized by a high risk of complications, primarily seromas. It is assumed that the cause of poor wound healing results in these patients may be proteolytic disorders. At the same time, it is believed that some biological markers can be considered as factors for predicting the risk of complications. The aim of the work was to analyze the literature data on the role of biologically active substances as risk factors for the development of complications of abdominoplasty. Results. A number of studies have demonstrated the different effects of body contouring surgery on glucose metabolism. At the same time, there was a significant improvement in insulin sensitivity after the interventions, but no significant normalization of fasting glucose levels was detected. Information about changes in the lipid profile of patients undergoing plastic surgery is contradictory, and a number of studies have noted a significant normalization of high-density lipoprotein levels. In the light of modern ideas about the role of adipose tissue as a source of pro-inflammatory cytokines (in particular, interleukin-4), it is obvious that liposuction during abdominoplasty can help reduce the severity of inflammatory reactions in the body. Attention is drawn to the possibility of using C-reactive protein as a marker for predicting complications during body contouring. The prospects of evaluating the activity of enzymes of the matrix metalloproteinase family, whose role as pro-inflammatory mediators and modulators of immunity is currently widely recognized, are noted. Conclusion. It is concluded that it is necessary to further improve the tools for predicting the development of complications during plastic surgery, in particular abdominal and contouring.