Metabolic disorders and functional status of the liver in workers of oil production enterprises

A survey of employees of the oil production enterprise was conducted. The intake of aromatic hydrocarbons in the body is accompanied by the formation of aggressive metabolites that activate lipid peroxidation, which initiates the inflammatory process, with the formation of vasoconstrictive inflammatory mediators. 47 workers involved in oil and gas production were examined; average age 38.8 years, average experience 10.5 years. The comparison group consisted of 47 employees of the administration of the same enterprise; average age 36.8 years; average experience of 9.7 years. Analysis of working conditions showed that the levels of aliphatic limit C1-10 (in terms of carbon) hydrocarbons in the air of the working zone exceeded hygienic standards, concentrations reached 1792.8 mg / m3. The relationship between metabolic disturbances and manifestations of non-alcoholic fatty hepatosis in oil workers under conditions of exposure to hydrocarbons was revealed. It is established that metabolic disorders are a pathogenetic link in the formation of non-alcoholic fatty liver disease.