Methods of intraoperative correction of hepatic dysfunction

The hepatobiliary system pathology remains an urgent problem of modern medicine. The liver regeneration ability largely determines the outcome of surgery and postoperative complications. The aim of the study was to enhance the prevention of postoperative hepatic dysfunction by activating methylation processes. The study involved experimental and clinical phases. In the experimental unit, the best results (15,17% acceleration of liver mass recovery) were observed with intrahepatic administration of cyanocobalamin, and intrahepatic administration of cyanocobalamin with intraperitoneal administration of ademethionine (12,04% acceleration). In clinical conditions, intravenous administration of cyanocobalamin and ademethionine contributed to the normalization of indicators of cholestasis syndrome, hepatic cell insufficiency and inflammation, a decrease in cytolysis, hepatic cell insufficiency. Thus, the proposed method of activation of methylation processes allows to increase the reparative potential of the liver, ensures the restoration of its anatomical and functional integrity, prevents the development of postoperative hepatic dysfunction.