Use of progesterone receptor blockers and F2 prostaglandins in treatment of pyometra of dogs

The pyometra of dogs is a pathology that needs urgent treatment, since the lack of timely therapy can result in animals’ death. Widely spread complications of this disease are septic shock, peritonitis, disseminated bacterial infection and multiple organ failure. The research was aimed to study the methods of conservative treatment of pyometra of dogs and the use of blockers of progesterone receptors and prostaglandins F2α in comparison. The study was carried out with 12 medium-sized dogs with a pyometra diagnosis. The average age of dogs is 10 years old. The diagnosis was based on the clinical picture, the results of a general blood test, ultrasound diagnosis. The dogs were divided into 2 equal groups of 6 individuals in each group. Pathogenesis and etiology of pyometra of dogs are not fully understood, therefore, surgical intervention is an effective and widespread method of treating of this disease. Unfortunately, this method is not suitable for all animals because of suspected anesthesia risks, impossibility of carrying out an operation, or for animals of high breeding value. Accordingly, it is relevant to study issues of methods of conservative treatment of pyometra of dogs, which would compete in efficiency with surgical method. The treatment of pyometra of dogs with the combination of aglepristone and cloprostenol showed high efficiency and a low risk of complications. The use of progesterone receptor blockers without F2α prostaglandins has good treatment results, but a slightly prolonged recovery period for patients.