Methodological approaches to creation of enriched food products with proven efficiency

The work suggests a methodology for obtaining healthy diet food products with proven effectiveness. In recent years, the production of food products enriched with biologically active substances is one of the most popular areas in various fields of the food industry. At the same time, there is a necessity to confirm the declared beneficial effects of food product enrichment. The organization of clinical research, as a rule, is associated with significant financial, time and labour costs. In this connection, there appears a necessity to develop an adequate pre-clinical research algorithm for the effectiveness of food products enriched with biologically active substances. Development of a food matrix and development of systems for biologically active substances delivery, such as microemulsions, liposomes, microgels, nano-emulsions, conjugates, microclusters, and others, take a special place in the confirmation of an enriched food product effectiveness. In spite of the array of data related to the study of various delivery systems, the problems of determining the mechanisms of chemical transformations when embedding encapsulated biologically active substances in the food matrix, their translation into the cellular systems of the human body, and participation in metabolic processes remain unsolved. The abovementioned should be taken into account when assessing the enriched food product effectiveness. It is equally important to analyze the consumer perception of enriched food, assess the technological accessibility of their production, the sufficiency of resource provision. On the basis of scientific literature analysis, there is taken an attempt to formulate a methodology for the development of the product, enriched with biologically active substances, with proven effectiveness, which grounds on a comprehensive, interdisciplinary approach to the organization of pre-clinical studies, including in vitro, in silico, and in vivo methods.