Urine microalbumin - a highly informative, simple and accessible hydrahydration prediction marker for infusion therapy in patients with abdominal sepsis

Syndrome of increased vascular permeability (SPS) is an important link in the pathogenesis of systemic inflammatory response (SVR) and systemic vascular endothelial damage in sepsis. An open, prospective cohort study was conducted in 70 patients with abdominal sepsis in order to identify the most prognostically significant markers of the development of CVD. All patients underwent tests for the presence of increased vascular permeability (urine albumin, urine microalbumin, urine albumin / creatinine ratio) and a starting “infusion load” test with a balanced crystalloid solution. Key indicators of central and peripheral hemodynamics were evaluated before and after infusion. As a result of the study, data were obtained that tests for “capillary leakage” are prognostically significant for assessing the severity of damage to the vascular wall in abdominal sepsis. The use of a urine microalbumin test allows predicting the development of hyperhydration during early infusion therapy in ICU patients with abdominal sepsis.