Микробиом и мозг: кишечная микробиота и нейроэндокринная система

Микробиом и мозг: кишечная микробиота и нейроэндокринная система

Автор: Булгакова Светлана Викторовна, Романчук Наталья Петровна, Тренева Екатерина Вячеславовна

Журнал: Бюллетень науки и практики @bulletennauki

Рубрика: Медицинские науки

Статья в выпуске: 6 т.8, 2022 года.

Бесплатный доступ

Микробная экосистема, населяющая желудочно-кишечный тракт всех млекопитающих, - кишечная микробиота - на протяжении многих тысячелетий находится в симбиотических отношениях со своими хозяевами. Благодаря современным технологиям выясняется множество функций организма, которые контролируются или модулируются кишечной микробиотой. Одной из систем, тесно взаимосвязанных с кишечной микробиотой, является нейроэндокринная система, контролирующая различные процессы в организме в ответ на стресс, а именно гипоталамо-гипофизарно-надпочечниковая ось (HPA). В настоящей статье описывается двунаправленная связь между кишечной микробиотой и осью HPA, обсуждаются лежащие в ее основе механизмы и связи с другими системами организма, такими как иммунная, вегетативная, центральная нервная системы, органы чувств, кишечный и гематоэнцефалический барьеры. Проведен анализ полезной роли пробиотиков и пребиотиков, вклад приема антибактериальных препаратов.

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Микробиом, мозг, кишечная микробиота, гипоталамо-гипофизарно-надпочечниковая ось, пробиотик, пребиотик, нейроэндокринная система

Короткий адрес: https://sciup.org/14124469

IDR: 14124469   |   DOI: 10.33619/2414-2948/79/32

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