МикроРНК, ВПЧ-инфекция и цервикальный канцерогенез: молекулярные аспекты и перспективы клинического использования

Автор: Архангельская Полина Анатольевна, Бахидзе Елена Вилльевна, Берлев Игорь Викторович, Самсонов Роман Борисович, Иванов Михаил Константинович, Малек Анастасия Валерьевна

Журнал: Сибирский онкологический журнал @siboncoj

Рубрика: Обзоры

Статья в выпуске: 4 (76), 2016 года.

Бесплатный доступ

Рак шейки матки (РШМ) является одним из самых распространенных онкологических заболеваний женской репродуктивной системы и одной из лидирующих причин женской онкологической смертности. Эпидемиологические и экспериментальные данные достоверно доказывают ключевую роль вируса папилломы человека (ВПЧ) в патогенезе РШМ. Определение ДНК ВПЧ высокого канцерогенного риска является актуальным скрининговым методом для выявления пациенток с повышенным риском развития цервикальной неоплазии. Однако положительная предсказательная ценность такого анализа недостаточно высока. Анализ дополнительных показателей инфекционного процесса (вирусная нагрузка, соотношение эписомальной и интегрированной форм вируса, длительность его персистенции) может быть использован для повышения диагностической и прогностической значимости ВПЧ-тестирования. В исследованиях последнего десятилетия показано, что ВПЧ индуцирует специфические изменения профиля микроРНК инфицированной клетки, которые отражают этапность заболевания и могут иметь диагностическое / прогностическое значение. В обзоре кратко изложены современные представления об изменениях профиля клеточных микроРНК, вызываемых инфицированием ВПЧ эпителия шейки матки, приведены известные примеры участия микроРНК в цервикальном канцерогенезе и обозначены перспективы возможного использования микроРНК в качестве биомаркеров в диагностике РШМ.

Еще

Рак шейки матки, цервикальный канцерогенез, вирус папилломы человека, впч, микрорнк

Короткий адрес: https://sciup.org/140253953

IDR: 140253953 | DOI: 10.21294/1814-4861-2016-15-4-88-97

Список литературы МикроРНК, ВПЧ-инфекция и цервикальный канцерогенез: молекулярные аспекты и перспективы клинического использования

World Cancer Report 2014/Stewart B.W., Wild C.P. France: WHO Press, 2014, 630 p.
Злокачественные новообразования в России в 2012 году (заболеваемость и смертность)/Под ред. А.Д. Каприна, В.В. Старинского, Г.В. Петрова. Москва; 2014, 250 с.
Мерабишвили В.М., Бахидзе Е.В., Лалианци Э.И., Урманчеева А.Ф., Красильников И.А. Распространенность гинекологического рака и выживаемость больных. Вопросы онкологии, 2014; 60 (3): 288-297.
Chen Z., Schiffman M., Herrero R., Desalle R., Anastos K., Segondy M., Sahasrabuddhe V.V., Gravitt P.E., Hsing A.W., Burk R.D. Evolution and taxonomic classification of human papillomavirus 16 (HPV16)related variant genomes: HPV31, HPV33, HPV35, HPV52, HPV58and HPV67. PLoS One. 2011; 6 (5): e20183. pone.0020183 DOI: 10.1371/journal
Евстигнеева Л.А., Бахидзе Е.В., Семиглазов В.В., Шипицына Е.В., Золотоверхая Е.А. Роль вирусологических факторов в развитии рака шейки матки у молодых женщин. Журнал акушерства и женских болезней. 2007; 7 (5): 153.
Коломиец Л.А., Уразова Л.Н., Севастьянова Н.В., Чуруксаева О.Н. Клинико-морфологические аспектыцервикальнойпапилломавирусной инфекции. Вопросы онкологии. 2002; 48 (1): 43-46.
Bosch F.X., Burchell A.N., Schiffman M., Giuliano A.R., de Sanjose S., Bruni L., Tortolero-Luna G., Kjaer S.K., Munoz N. Epidemiology and natural history of human papillomavirus infections and type-specific implications in cervical neoplasia. Vaccine. 2008 Aug 19; 26 Suppl 10: K1-16 DOI: 10.1016/j.vaccine.2008.05.064
Киселев В.И., Киселев О.И. Этиологическая роль вируса папилломы человека в развитии рака шейки матки: генетические и патогенетические механизмы. Цитокины и воспаление. 2003; 2 (4): 31-38.
Dillner J., Rebolj M., Birembaut Ph., Petry K.U., Szarewski A., Munk C., de Sanjose S., Naucler P., Lloveras B., Kjaer S., Cuzick J., van Ballegooijen M., Clavel C., Iftner T.; Joint European Cohort Study. Long term predictive values of cytology and human papillomavirus testing in cervical cancer screening: joint European cohort study. BMJ. 2008 Oct 13; 337: a1754 DOI: 10.1136/bmj.a1754
Киселева В.И., Крикунова Л.И., Любина Л.В., Мкртчян Л.С., Безяева Г.П., Панарина Л.В., Скугарев С.А., Куевда Д.А., Трофимова О.В., Саенко А.С. Количественная нагрузка вируса папилломы человека 16 типа и прогнозирование эффективности лечения рака шейки матки. Радиация и риск. 2011; 20 (2): 58-63.
Комарова Е.В., Минкна Г.Н., Гаврикова М.В., Храмова О.К. Вирус папилломы человека -тестирование и генотипирование в диагностике цервикальных интраэпителиальных неоплазий. Медицина критических состояний. 2010; 1 (1): 54-61.
Marks M., Gravitt P.E., Utaipat U., Gupta S.B., Liaw K., Kim E., Tadesse A., Phongnarisorn C., Wootipoom V., Yuenyao P., Vipupinyo C., Rugpao S., Sriplienchan S., Celentano D.D. Kinetics of DNA load predict HPV 16 viral clearance. J Clin Virol. 2011 May;51(1):44-9. doi: 10.1016/j. jcv.2011.01.011.
Колесников Н.Н., Титов С.Е., Веряскина Ю.А., Карпинская Е.В., Шевченко С.П., Ахмерова Л.Г., Иванов М.К., Козлов В.В., Елисафенко Е.А., Гуляева Л.Ф., Жимулев И.Ф. МикроРНК, эволюция и рак. Цитология. 2013; 55 (3): 159-164.
Di Leva G., Garofalo M., Croce C.M. MicroRNAs in cancer. Annu Rev Pathol. 2014;9:287-314 DOI: 10.1146/annurev-pathol-012513104715
Pedroza-Torres A., Lopez-Urrutia E., Garcia-Castillo V., Jacobo-Herrera N., Herrera L.A., Peralta-Zaragoza O., Lopez-Camarillo C., De Leon D.C., Fernandez-Retana J., Cerna-Cortes J.F., Perez-Plasencia C. MicroRNAs in cervical cancer: evidences for a miRNAprofile deregulated by HPV and its impact on radio-resistance. Molecules. 2014 May 16; 19 (5): 6263-81 DOI: 10.3390/molecules19056263
Au Yeung C.L., Tsang T.Y., Yau P.L., Kwok T.T. Human papilloma-virus type 16 E6 induces cervical cancer cell migration through the p53/microRNA-23b/urokinase-type plasminogen activator pathway. Oncogene. 2011 May 26; 30 (21): 2401-10 DOI: 10.1038/onc.2010.613
Greco D., Kivi N., Qian K., Leivonen S.K., Auvinen P., Auvinen E. Human papillomavirus 16 E5 modulates the expression of host microRNAs. PLoS One. 2011; 6 (7): e21646 DOI: 10.1371/journal.pone.0021646
Bernard X., Robinson P., Nomine Y., Masson M., Charbonnier S., Ramirez-Ramos J.R., Deryckere F., Trave G., Orfanoudakis G. Proteasomal degradation of p53 by human papillomavirus E6 oncoprotein relies on the structural integrity of p53 core domain. PLoS One. 2011; 6 (10): e25981 DOI: 10.1371/journal.pone.0025981
Nomine Y., Masson M., Charbonnier S., Zanier K., Ristriani T., Deryckere F., Sibler A. P., Desplancq D., Atkinson R. A., Weiss E., Orfanoudakis G., Kieffer B., Trave G. Structural and functional analysis of E6 oncoprotein: insights in the molecular pathways of human papillomavirusmediated pathogenesis. Mol Cell. 2006 Mar 3; 21 (5): 665-78.
Wang X., Wang H.K., McCoy J.P., Banerjee N.S., Rader J.S., Broker T.R., Meyers C., Chow L.T., Zheng Z.M. Oncogenic HPV infection interrupts the expression of tumor-suppressive miR-34a through viral oncoprotein E6. RNA. 2009 Apr; 15 (4): 637-47 DOI: 10.1261/rna.1442309
Turner M.A., Palefsky J.M. Urokinase plasminogen activator expression by primary and HPV 16-transformed keratinocytes. Clin Exp Metastasis. 1995 Jul; 13 (4): 260-8.
Martinez I., Gardiner A.S., Board K.F., Monzon F.A., Edwards R.P., Khan S.A. Human papillomavirus type 16 reduces the expression of microRNA-218 in cervical carcinoma cells. Oncogene. 2008 Apr 17; 27 (18): 2575-82.
Myklebust M.P., Bruland O., Fluge O., Skarstein A., Balteskard L., Dahl O. MicroRNA-15b is induced with E2F-controlled genes in HPV-related cancer. Br J Cancer. 2011 Nov 22; 105 (11): 1719-25 DOI: 10.1038/bjc.2011.457
Yamamoto N., Kinoshita T., Nohata N., Itesako T., Yoshino H., Enokida H., Nakagawa M., Shozu M., Seki N. Tumor suppressive microRNA-218 inhibits cancer cell migration and invasion by targeting focal adhesion pathways in cervical squamous cell carcinoma. Int J Oncol. 2013 May; 42(5): 1523-32 DOI: 10.3892/ijo.2013.1851
Banno K., Iida M., Yanokura M., Kisu I., Iwata T., Tominaga E., Tanaka K., Aoki D. MicroRNA in cervical cancer: OncomiRs and tumor suppressor miRs in diagnosis and treatment. Scientific World J. 2014 Jan 2; 2014: 178075 DOI: 10.1155/2014/178075
Gocze K., Gombos K., Kovacs K., Juhasz K., Gocze P., Kiss I. MicroRNA expressions in HPV-induced cervical dysplasia and cancer. Anticancer Res. 2015 Jan; 35 (1): 523-30.
Kogo R., How C., Chaudary N., Bruce J., Shi W., Hill R.P., Zahedi P., Yip K.W., Liu F.F. The microRNA-218~Survivin axis regulates migration, invasion, and lymph node metastasis in cervical cancer. Oncotarget. 2015 Jan 20; 6 (2): 1090-100.
Campos-Viguri G.E., Jimenez-Wences H., Peralta-Zaragoza O., Torres-Altamirano G., Soto-Flores D.G., Hernandez-Sotelo D., Alarcon-Romero Ldel C., Jimenez-Lopez M.A., Illades-Aguiar B., Fernandez-Tilapa G.miR-23b as a potential tumor suppressor and its regulation by DNAmethylation in cervical cancer. Infect Agent Cancer. 2015; 10: 42 DOI: 10.1186/s13027-015-0037-6
Honegger A., Schilling D., Bastian S., Sponagel J., Kuryshev V., Sultmann H., Scheffner M., Hoppe-Seyler K., Hoppe-Seyler F. Dependence of intracellular and exosomal microRNAs on viral E6/E7 oncogene expression in HPV-positive tumor cells. PLoS Pathog. 2015 Mar 11; 11 (3): e1004712 DOI: 10.1371/journal.ppat.1004712
Zheng Z.M., Wang X. Regulation of cellular miRNA expression by human papillomaviruses. Biochim Biophys Acta. 2011 Nov-Dec; 1809 (11-12): 668-77 DOI: 10.1016/j.bbagrm.2011.05.005
Ben W., Yang Y., Yuan J., Sun J., Huang M., Zhang D., Zheng J. Human papillomavirus 16 E6 modulates the expression of host microRNAs in cervical cancer. Taiwan J Obstet Gynecol. 2015 Aug; 54 (4): 364-70 DOI: 10.1016/j.tjog.2014.06.007
Wang X., Wang H.K., Li Y., Hafner M., Banerjee N.S., Tang S., Briskin D., Meyers C., Chow L.T., Xie X., Tuschl T., Zheng Z.M. micro-RNAs are biomarkers of oncogenic human papillomavirus infections.Proc Natl Acad Sci USA. 2014 Mar 18; 111 (11): 4262-7 DOI: 10.1073/pnas.1401430111
Wang L., Yu J., Xu J., Zheng C., Li X., Du J. The analysis of microRNA-34 family expression in human cancer studies comparing cancer tissues with corresponding pericarcinous tissues. Curr Pharm Des. 2014; 20 (11): 1639-46.
Yuan F., Sun R., Chen P., Liang Y., Ni S., Quan Y., Huang J., Zhang L., Gao L. Combined analysis of pri-miR-34b/c rs4938723 and TP53 Arg72Pro with cervical cancer risk. Tumour Biol. 2016 May; 37 (5): 6267-73 DOI: 10.1007/s13277-015-4467-y
Chen Y., Ma C., Zhang W., Chen Z., Ma L. Down regulation of miR-143 is related with tumor size, lymph node metastasis and HPV16 infection in cervical squamous cancer. Diagn Pathol. 2014 Apr 28; 9: 88 DOI: 10.1186/1746-1596-9-88
Liu L., Wang Y.L., Wang J.F. Differential expression of miR-21, miR-126, miR-143, miR-373 in normal cervical tissue, cervical cancer tissue and Hela cell. Sichuan Da Xue Xue Bao Yi Xue Ban. 2012 Jul; 43 (4): 536-9.
Yuan W., Xiaoyun H., Haifeng Q., Jing L., Weixu H., Ruofan D., Jinjin Y., Zongji S. MicroRNA-218 enhances the radiosensitivity of human cervical cancer via promoting radiation induced apoptosis. Int J Med Sci. 2014 May 6; 11 (7): 691-6 DOI: 10.7150/ijms.8880
ZHu Y.K., Cheng N., Hu Y., Cen Y.Z. The role of microRNAs in the pathogenesis of cervical cancer and its relationship to HPV. Sheng Li Ke Xue Jin Zhan. 2012 Aug; 43 (4): 251-6.
Botezatu A., Goia-Rusanu C.D., Iancu I.V., Huica I., Plesa A., Socolov D., Ungureanu C., Anton G. Quantitative analysis of the relationship between microRNA124a, -34b and -203 gene methylation and cervical oncogenesis. Mol Med Rep. 2011 Jan-Feb;4 (1): 121-8 DOI: 10.3892/mmr.2010.394
Seifoleslami M., Khameneie M.K., Mashayekhi F., Sedaghati F., Ziari K., Mansouri K., Safari A. Identification of microRNAs (miR-203/miR-7) as potential markers for the early detection of lymph node metastases in patients with cervical cancer. Tumour Biol. 2015 Oct 22.
Zhu X., Er K., Mao C., Yan Q., Xu H., Zhang Y., Zhu J., Cui F., Zhao W., Shi H. miR-203 suppresses tumor growth and angiogenesis by targeting VEGFA in cervical cancer. Cell Physiol Biochem. 2013; 32 (1): 64-73 DOI: 10.1159/000350125
Lee J.W., Choi C.H., Choi J.J., Park Y.A., Kim S.J., Hwang S.Y., Kim W.Y., Kim T.J., Lee J.H., Kim B.G., Bae D.S. Altered MicroRNA expression in cervical carcinomas. Clin Cancer Res. 2008 May 1; 14 (9): 2535-42 DOI: 10.1158/1078-0432.CCR-07-1231
You W., Wang Y., Zheng J. Plasma miR-127 and miR-218 Might Serve as Potential Biomarkers for Cervical Cancer. Reprod Sci. 2015Aug; 22 (8): 1037-41 DOI: 10.1177/1933719115570902
Tian Q., Li Y., Wang F., Li Y., Xu J., Shen Y., Ye F., Wang X., Cheng X., Chen Y., Wan X., Lu W., Xie X. MicroRNA detection in cervical exfoliated cells as a triage for human papillomavirus-positive women. J Natl Cancer Inst. 2014 Sep 4; 106 (9). pii: dju241 DOI: 10.1093/jnci/dju241
Han Y., Xu G.X., Lu H., Yu D.H., Ren Y., Wang L., Huang X.H., Hou W.J., Wei Z.H., Chen Y.P., Cao Y.G., Zhang R. Dysregulation of miRNA-21 and their potential as biomarkers for the diagnosis of cervical cancer. Int J Clin Exp Pathol. 2015 Jun 1; 8 (6): 7131-9.
Shishodia G., Shukla S., Srivastava Y., Masaldan S., Mehta S., Bhambhani S., Sharma S., Mehrotra R., Das B.C., Bharti A.C. Alterations in microRNAs miR-21 and let-7a correlate with aberrant STAT3 signaling and downstream effects during cervical carcinogenesis. Mol Cancer. 2015 Jun 9; 14: 116 DOI: 10.1186/s12943-015-0385-2
Leonard S.M., Wei W., Collins S.I., Pereira M., Diyaf A., Constandinou-Williams C., Young L.S., Roberts S., Woodman C.B. Oncogenichuman papillomavirus imposes an instructive pattern of DNA methylation changes which parallel the natural history of cervical HPV infection in young women. Carcinogenesis. 2012 Jul; 33 (7): 1286-93. doi: 10.1093/carcin/bgs157.
Burgers W.A., Blanchon L., Pradhan S., de Launoit Y., Kouzarides T., Fuks F. Viral oncoproteins target the DNA methyltransferases. Oncogene. 2007 Mar 8; 26 (11): 1650-5.
Jimenez-Wences H., Peralta-Zaragoza O., Fernandez-Tilapa G. Human papilloma virus, DNA methylation and microRNA expression in cervical cancer (Review). Oncol Rep. 2014 Jun; 31 (6): 2467-76 DOI: 10.3892/or.2014.3142
Wilting S.M., van Boerdonk R.A., Henken F.E., Meijer C.J., Dios-dado B., Meijer G.A., le Sage C., Agami R., Snijders P.J., Steenbergen R.D. Methylation-mediated silencing and tumour suppressive function of hsa-miR-124 in cervical cancer. Mol Cancer. 2010 Jun 26; 9: 167 DOI: 10.1186/1476-4598-9-167
Wang J.T., Ding L., Jiang S.W., Hao J., Zhao W.M., Zhou Q., Yang Z.K., Zhang L. Folate deficiency and aberrant expression of DNA methyltransferase 1 were associated with cervical cancerization. Curr Pharm Des. 2014; 20 (11): 1639-46.
Hu Z., Zhu D., Wang W., Li W., Jia W., Zeng X., Ding W., Yu L., Wang X., Wang L., Shen H., Zhang C., Liu H., Liu X., Zhao Y., Fang X., Li S., Chen W., Tang T., Fu A., Wang Z., Chen G., Gao Q., Li S., Xi L., Wang C., Liao S., Ma X., Wu P., Li K., Wang S., Zhou J., Wang J., Xu X., Wang H., Ma D. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomologymediated integration mechanism. Nat Genet. 2015 Feb; 47 (2): 158-63 DOI: 10.1038/ng.3178
Calin G.A., Sevignani C., Dumitru C.D., Hyslop T., Noch E., Yendamuri S., Shimizu M., Rattan S., Bullrich F., Negrini M., Croce C.M.Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci USA. 2004 Mar 2; 101 (9): 2999-3004.
Wentzensen N., Vinokurova S., von Knebel Doeberitz M. Systematic review of genomic integration sites of human papillomavirus genomes in epithelial dysplasia and invasive cancer of the female lower genital tract.Cancer Res. 2004 Jun 1; 64 (11): 3878-84.
Zubillaga-Guerrero M.I., Alarcon-Romero L de lC., Illades-AguiarB., Flores-Alfaro E., Bermudez-Morales V.H., Deas J., Peralta-Zaragoza O. MicroRNA miR-16-1 regulates CCNE1 (cyclin E1) gene expression in human cervical cancer cells. Int J Clin Exp Med. 2015 Sep 15; 8 (9): 15999-6006.
Gunasekharan V., Laimins L.A. Human papillomaviruses modulate microRNA145 expression to directly control genome amplification. J Virol. 2013 May; 87 (10): 6037-43 DOI: 10.1128/JVI.00153-13
Tian Q., Li Y., Wang F., Li Y., Xu J., Shen Y., Ye F., Wang X., Cheng X., Chen Y., Wan X., Lu W., Xie X. MicroRNA detection in cervical exfoliated cells as a triage for human papillomavirus-positive women. J Natl Cancer Inst. 2014 Sep 4; 106 (9). pii: dju241 DOI: 10.1093/jnci/dju241
Ribeiro J., Marinho-Dias J., Monteiro P., Loureiro J., Baldaque I., Medeiros R., Sousa H. miR-34a and miR-125b Expression in HPV Infection and Cervical Cancer Development Biomed Res Int. 2015; 2015: 304584 DOI: 10.1155/2015/304584
He Y., Lin J., Ding Y., Liu G., Luo Y., Huang M., Xu C., Kim T.K., Etheridge A., Lin M., Kong D., Wang K. Asystematic study on dysregulated microRNAs in cervical cancer development. Int J Cancer. 2016 Mar 15; 138 (6): 1312-27 DOI: 10.1002/ijc.29618
Mo W., Tong C., Zhang Y., Lu H. microRNAs’ differential regulations mediate the progress of Human Papillomavirus (HPV)-induced Cervical Intraepithelial Neoplasia (CIN). BMC Syst Biol. 2015 Feb 7; 9: 4 DOI: 10.1186/s12918-015-0145-3
Комарова Е.В., Минкна Г.Н., Гаврикова М.В., Храмова О.К. Вирус папилломы человека -тестирование и генотипирование в диагностике цервикальных интраэпителиальных неоплазий. Медицина критических состояний. 2010; 1 (1): 54-61.
Marks M., Gravitt P.E., Utaipat U., Gupta S.B., Liaw K., Kim E., Tadesse A., Phongnarisorn C., Wootipoom V., Yuenyao P., Vipupinyo C., Rugpao S., Sriplienchan S., Celentano D.D. Kinetics of DNA load predict HPV 16 viral clearance. J Clin Virol. 2011 May;51(1):44-9. doi: 10.1016/j. jcv.2011.01.011.
Колесников Н.Н., Титов С.Е., Веряскина Ю.А., Карпинская Е.В., Шевченко С.П., Ахмерова Л.Г., Иванов М.К., Козлов В.В., Елисафенко Е.А., Гуляева Л.Ф., Жимулев И.Ф. МикроРНК, эволюция и рак. Цитология. 2013; 55 (3): 159-164.
Di Leva G., Garofalo M., Croce C.M. MicroRNAs in cancer. Annu Rev Pathol. 2014;9:287-314 DOI: 10.1146/annurev-pathol-012513104715
Pedroza-Torres A., Lopez-Urrutia E., Garcia-Castillo V., Jacobo-Herrera N., Herrera L.A., Peralta-Zaragoza O., Lopez-Camarillo C., De Leon D.C., Fernandez-Retana J., Cerna-Cortes J.F., Perez-Plasencia C. MicroRNAs in cervical cancer: evidences for a miRNAprofile deregulated by HPV and its impact on radio-resistance. Molecules. 2014 May 16; 19 (5): 6263-81 DOI: 10.3390/molecules19056263
Au Yeung C.L., Tsang T.Y., Yau P.L., Kwok T.T. Human papilloma-virus type 16 E6 induces cervical cancer cell migration through the p53/microRNA-23b/urokinase-type plasminogen activator pathway. Oncogene. 2011 May 26; 30 (21): 2401-10 DOI: 10.1038/onc.2010.613
Greco D., Kivi N., Qian K., Leivonen S.K., Auvinen P., Auvinen E. Human papillomavirus 16 E5 modulates the expression of host microRNAs. PLoS One. 2011; 6 (7): e21646 DOI: 10.1371/journal.pone.0021646
Bernard X., Robinson P., Nomine Y., Masson M., Charbonnier S., Ramirez-Ramos J.R., Deryckere F., Trave G., Orfanoudakis G. Proteasomal degradation of p53 by human papillomavirus E6 oncoprotein relies on the structural integrity of p53 core domain. PLoS One. 2011; 6 (10): e25981 DOI: 10.1371/journal.pone.0025981
Nomine Y., Masson M., Charbonnier S., Zanier K., Ristriani T., Deryckere F., Sibler A. P., Desplancq D., Atkinson R. A., Weiss E., Orfanoudakis G., Kieffer B., Trave G. Structural and functional analysis of E6 oncoprotein: insights in the molecular pathways of human papillomavirusmediated pathogenesis. Mol Cell. 2006 Mar 3; 21 (5): 665-78.
Wang X., Wang H.K., McCoy J.P., Banerjee N.S., Rader J.S., Broker T.R., Meyers C., Chow L.T., Zheng Z.M. Oncogenic HPV infection interrupts the expression of tumor-suppressive miR-34a through viral oncoprotein E6. RNA. 2009 Apr; 15 (4): 637-47 DOI: 10.1261/rna.1442309
Turner M.A., Palefsky J.M. Urokinase plasminogen activator expression by primary and HPV 16-transformed keratinocytes. Clin Exp Metastasis. 1995 Jul; 13 (4): 260-8.
Martinez I., Gardiner A.S., Board K.F., Monzon F.A., Edwards R.P., Khan S.A. Human papillomavirus type 16 reduces the expression of microRNA-218 in cervical carcinoma cells. Oncogene. 2008 Apr 17; 27 (18): 2575-82.
Myklebust M.P., Bruland O., Fluge O., Skarstein A., Balteskard L., Dahl O. MicroRNA-15b is induced with E2F-controlled genes in HPV-related cancer. Br J Cancer. 2011 Nov 22; 105 (11): 1719-25 DOI: 10.1038/bjc.2011.457
Yamamoto N., Kinoshita T., Nohata N., Itesako T., Yoshino H., Enokida H., Nakagawa M., Shozu M., Seki N. Tumor suppressive microRNA-218 inhibits cancer cell migration and invasion by targeting focal adhesion pathways in cervical squamous cell carcinoma. Int J Oncol. 2013 May; 42(5): 1523-32 DOI: 10.3892/ijo.2013.1851
Banno K., Iida M., Yanokura M., Kisu I., Iwata T., Tominaga E., Tanaka K., Aoki D. MicroRNA in cervical cancer: OncomiRs and tumor suppressor miRs in diagnosis and treatment. Scientific World J. 2014 Jan 2; 2014: 178075 DOI: 10.1155/2014/178075
Gocze K., Gombos K., Kovacs K., Juhasz K., Gocze P., Kiss I. MicroRNA expressions in HPV-induced cervical dysplasia and cancer. Anticancer Res. 2015 Jan; 35 (1): 523-30.
Kogo R., How C., Chaudary N., Bruce J., Shi W., Hill R.P., Zahedi P., Yip K.W., Liu F.F. The microRNA-218~Survivin axis regulates migration, invasion, and lymph node metastasis in cervical cancer. Oncotarget. 2015 Jan 20; 6 (2): 1090-100.
Campos-Viguri G.E., Jimenez-Wences H., Peralta-Zaragoza O., Torres-Altamirano G., Soto-Flores D.G., Hernandez-Sotelo D., Alarcon-Romero Ldel C., Jimenez-Lopez M.A., Illades-Aguiar B., Fernandez-Tilapa G.miR-23b as a potential tumor suppressor and its regulation by DNAmethylation in cervical cancer. Infect Agent Cancer. 2015; 10: 42 DOI: 10.1186/s13027-015-0037-6
Honegger A., Schilling D., Bastian S., Sponagel J., Kuryshev V., Sultmann H., Scheffner M., Hoppe-Seyler K., Hoppe-Seyler F. Dependence of intracellular and exosomal microRNAs on viral E6/E7 oncogene expression in HPV-positive tumor cells. PLoS Pathog. 2015 Mar 11; 11 (3): e1004712 DOI: 10.1371/journal.ppat.1004712
Zheng Z.M., Wang X. Regulation of cellular miRNA expression by human papillomaviruses. Biochim Biophys Acta. 2011 Nov-Dec; 1809 (11-12): 668-77 DOI: 10.1016/j.bbagrm.2011.05.005
Ben W., Yang Y., Yuan J., Sun J., Huang M., Zhang D., Zheng J. Human papillomavirus 16 E6 modulates the expression of host microRNAs in cervical cancer. Taiwan J Obstet Gynecol. 2015 Aug; 54 (4): 364-70 DOI: 10.1016/j.tjog.2014.06.007
Wang X., Wang H.K., Li Y., Hafner M., Banerjee N.S., Tang S., Briskin D., Meyers C., Chow L.T., Xie X., Tuschl T., Zheng Z.M. micro-RNAs are biomarkers of oncogenic human papillomavirus infections.Proc Natl Acad Sci USA. 2014 Mar 18; 111 (11): 4262-7 DOI: 10.1073/pnas.1401430111
Wang L., Yu J., Xu J., Zheng C., Li X., Du J. The analysis of microRNA-34 family expression in human cancer studies comparing cancer tissues with corresponding pericarcinous tissues. Curr Pharm Des. 2014; 20 (11): 1639-46.
Yuan F., Sun R., Chen P., Liang Y., Ni S., Quan Y., Huang J., Zhang L., Gao L. Combined analysis of pri-miR-34b/c rs4938723 and TP53 Arg72Pro with cervical cancer risk. Tumour Biol. 2016 May; 37 (5): 6267-73 DOI: 10.1007/s13277-015-4467-y
Chen Y., Ma C., Zhang W., Chen Z., Ma L. Down regulation of miR-143 is related with tumor size, lymph node metastasis and HPV16 infection in cervical squamous cancer. Diagn Pathol. 2014 Apr 28; 9: 88 DOI: 10.1186/1746-1596-9-88
Liu L., Wang Y.L., Wang J.F. Differential expression of miR-21, miR-126, miR-143, miR-373 in normal cervical tissue, cervical cancer tissue and Hela cell. Sichuan Da Xue Xue Bao Yi Xue Ban. 2012 Jul; 43 (4): 536-9.
Yuan W., Xiaoyun H., Haifeng Q., Jing L., Weixu H., Ruofan D., Jinjin Y., Zongji S. MicroRNA-218 enhances the radiosensitivity of human cervical cancer via promoting radiation induced apoptosis. Int J Med Sci. 2014 May 6; 11 (7): 691-6 DOI: 10.7150/ijms.8880
ZHu Y.K., Cheng N., Hu Y., Cen Y.Z. The role of microRNAs in the pathogenesis of cervical cancer and its relationship to HPV. Sheng Li Ke Xue Jin Zhan. 2012 Aug; 43 (4): 251-6.
Botezatu A., Goia-Rusanu C.D., Iancu I.V., Huica I., Plesa A., Socolov D., Ungureanu C., Anton G. Quantitative analysis of the relationship between microRNA124a, -34b and -203 gene methylation and cervical oncogenesis. Mol Med Rep. 2011 Jan-Feb;4 (1): 121-8 DOI: 10.3892/mmr.2010.394
Seifoleslami M., Khameneie M.K., Mashayekhi F., Sedaghati F., Ziari K., Mansouri K., Safari A. Identification of microRNAs (miR-203/miR-7) as potential markers for the early detection of lymph node metastases in patients with cervical cancer. Tumour Biol. 2015 Oct 22.
Zhu X., Er K., Mao C., Yan Q., Xu H., Zhang Y., Zhu J., Cui F., Zhao W., Shi H. miR-203 suppresses tumor growth and angiogenesis by targeting VEGFA in cervical cancer. Cell Physiol Biochem. 2013; 32 (1): 64-73 DOI: 10.1159/000350125
Lee J.W., Choi C.H., Choi J.J., Park Y.A., Kim S.J., Hwang S.Y., Kim W.Y., Kim T.J., Lee J.H., Kim B.G., Bae D.S. Altered MicroRNA expression in cervical carcinomas. Clin Cancer Res. 2008 May 1; 14 (9): 2535-42 DOI: 10.1158/1078-0432.CCR-07-1231
You W., Wang Y., Zheng J. Plasma miR-127 and miR-218 Might Serve as Potential Biomarkers for Cervical Cancer. Reprod Sci. 2015Aug; 22 (8): 1037-41 DOI: 10.1177/1933719115570902
Tian Q., Li Y., Wang F., Li Y., Xu J., Shen Y., Ye F., Wang X., Cheng X., Chen Y., Wan X., Lu W., Xie X. MicroRNA detection in cervical exfoliated cells as a triage for human papillomavirus-positive women. J Natl Cancer Inst. 2014 Sep 4; 106 (9). pii: dju241 DOI: 10.1093/jnci/dju241
Han Y., Xu G.X., Lu H., Yu D.H., Ren Y., Wang L., Huang X.H., Hou W.J., Wei Z.H., Chen Y.P., Cao Y.G., Zhang R. Dysregulation of miRNA-21 and their potential as biomarkers for the diagnosis of cervical cancer. Int J Clin Exp Pathol. 2015 Jun 1; 8 (6): 7131-9.
Shishodia G., Shukla S., Srivastava Y., Masaldan S., Mehta S., Bhambhani S., Sharma S., Mehrotra R., Das B.C., Bharti A.C. Alterations in microRNAs miR-21 and let-7a correlate with aberrant STAT3 signaling and downstream effects during cervical carcinogenesis. Mol Cancer. 2015 Jun 9; 14: 116 DOI: 10.1186/s12943-015-0385-2
Leonard S.M., Wei W., Collins S.I., Pereira M., Diyaf A., Constandinou-Williams C., Young L.S., Roberts S., Woodman C.B. Oncogenichuman papillomavirus imposes an instructive pattern of DNA methylation changes which parallel the natural history of cervical HPV infection in young women. Carcinogenesis. 2012 Jul; 33 (7): 1286-93. doi: 10.1093/carcin/bgs157.
Burgers W.A., Blanchon L., Pradhan S., de Launoit Y., Kouzarides T., Fuks F. Viral oncoproteins target the DNA methyltransferases. Oncogene. 2007 Mar 8; 26 (11): 1650-5.
Jimenez-Wences H., Peralta-Zaragoza O., Fernandez-Tilapa G. Human papilloma virus, DNA methylation and microRNA expression in cervical cancer (Review). Oncol Rep. 2014 Jun; 31 (6): 2467-76 DOI: 10.3892/or.2014.3142
Wilting S.M., van Boerdonk R.A., Henken F.E., Meijer C.J., Dios-dado B., Meijer G.A., le Sage C., Agami R., Snijders P.J., Steenbergen R.D. Methylation-mediated silencing and tumour suppressive function of hsa-miR-124 in cervical cancer. Mol Cancer. 2010 Jun 26; 9: 167 DOI: 10.1186/1476-4598-9-167
Wang J.T., Ding L., Jiang S.W., Hao J., Zhao W.M., Zhou Q., Yang Z.K., Zhang L. Folate deficiency and aberrant expression of DNA methyltransferase 1 were associated with cervical cancerization. Curr Pharm Des. 2014; 20 (11): 1639-46.
Hu Z., Zhu D., Wang W., Li W., Jia W., Zeng X., Ding W., Yu L., Wang X., Wang L., Shen H., Zhang C., Liu H., Liu X., Zhao Y., Fang X., Li S., Chen W., Tang T., Fu A., Wang Z., Chen G., Gao Q., Li S., Xi L., Wang C., Liao S., Ma X., Wu P., Li K., Wang S., Zhou J., Wang J., Xu X., Wang H., Ma D. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomologymediated integration mechanism. Nat Genet. 2015 Feb; 47 (2): 158-63 DOI: 10.1038/ng.3178
Calin G.A., Sevignani C., Dumitru C.D., Hyslop T., Noch E., Yendamuri S., Shimizu M., Rattan S., Bullrich F., Negrini M., Croce C.M.Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci USA. 2004 Mar 2; 101 (9): 2999-3004.
Wentzensen N., Vinokurova S., von Knebel Doeberitz M. Systematic review of genomic integration sites of human papillomavirus genomes in epithelial dysplasia and invasive cancer of the female lower genital tract.Cancer Res. 2004 Jun 1; 64 (11): 3878-84.
Zubillaga-Guerrero M.I., Alarcon-Romero L de lC., Illades-AguiarB., Flores-Alfaro E., Bermudez-Morales V.H., Deas J., Peralta-Zaragoza O. MicroRNA miR-16-1 regulates CCNE1 (cyclin E1) gene expression in human cervical cancer cells. Int J Clin Exp Med. 2015 Sep 15; 8 (9): 15999-6006.
Gunasekharan V., Laimins L.A. Human papillomaviruses modulate microRNA145 expression to directly control genome amplification. J Virol. 2013 May; 87 (10): 6037-43 DOI: 10.1128/JVI.00153-13
Tian Q., Li Y., Wang F., Li Y., Xu J., Shen Y., Ye F., Wang X., Cheng X., Chen Y., Wan X., Lu W., Xie X. MicroRNA detection in cervical exfoliated cells as a triage for human papillomavirus-positive women. J Natl Cancer Inst. 2014 Sep 4; 106 (9). pii: dju241 DOI: 10.1093/jnci/dju241
Ribeiro J., Marinho-Dias J., Monteiro P., Loureiro J., Baldaque I., Medeiros R., Sousa H. miR-34a and miR-125b Expression in HPV Infection and Cervical Cancer Development Biomed Res Int. 2015; 2015: 304584 DOI: 10.1155/2015/304584
He Y., Lin J., Ding Y., Liu G., Luo Y., Huang M., Xu C., Kim T.K., Etheridge A., Lin M., Kong D., Wang K. Asystematic study on dysregulated microRNAs in cervical cancer development. Int J Cancer. 2016 Mar 15; 138 (6): 1312-27 DOI: 10.1002/ijc.29618
Mo W., Tong C., Zhang Y., Lu H. microRNAs’ differential regulations mediate the progress of Human Papillomavirus (HPV)-induced Cervical Intraepithelial Neoplasia (CIN). BMC Syst Biol. 2015 Feb 7; 9: 4 DOI: 10.1186/s12918-015-0145-3

Еще

Статья научная