Mineral density of bone tissue in patients with lower limb diabetic involvement

The authors have come to the conclusion that both the decreased formation of bone tissue and the decrease of osteoclasts in number dominate in case of I-type diabetes mellitus. While studying bone metabolism markers the decrease of osteocalcin content is found to be the most frequent and constant value. The pathogenetic role of glucocorticoids is being discussed, as well as that of parathyroid and sex hormones, calcitonin, vitamin D active metabolites, local factors and microangiopathy. Local factors such as IGF-I, IGF-II, prostaglandins, cytokines (interleukins including) are involved in the mechanism of osteopenia development. Diabetic microangiopathy is of more vital importance in the mechanisms of diabetic osteoarthropathy and local demineralization development. Mineral density tends to be decreased to a greater extent in women, than in men.