Modification of antitumor therapy with antioxidant drugs in experimental studies

We investigated ability of broad spectrum antioxidants - emoxipinum (3-oxy-6-metyl-2-etyl-piridin hydrochloridum) and alphatocopheryl acetate, to control the oxidative damage induced by some antitumor drugs (cyclophosphamide, 5-fluorouracil, rubomycine). Studies were performed on rats with transplantable cholangiocellular RS-1 carcinoma. Biochemical methods were used for this investigation. The rats that were subjected to combination antioxidants and antitumor drug had normalized of lipid peroxidation in the liver and renal tissue compared the group treated with antitumor drug only. Also, emoxipinum inhibited chemotherapy-induced leucopenia. The activity of tumor antioxidative enzymes was significantly decreased and tumor malondialdehyde (MDA) level was increased in the study group compared to the group only treated with antitumor drug (р