Molecular-genetic determinants of chronic heart failure associated with type 2 diabetes and osteoporosis

This article presents the results of a study on the molecular-genetic factors influencing the development of chronic heart failure (CHF) comorbid with type 2 diabetes mellitus (T2DM) and osteoporosis in postmenopausal women. Polymorphic variants of the IL-1β, eNOS, and angiotensinogen genes were found to be associated with an increased risk of CHF in the presence of T2DM. Alleles and genotypes that can serve as predictors of disease progression were identified. Based on the obtained data, strategies for a personalized approach to the diagnosis and secondary prevention of CHF are proposed. The results emphasize the importance of genetic analysis for improving the prediction of cardiovascular complications and planning therapeutic measures.