Molecular genetic analysis of the CYP11B2 gene associated with the development of arterial hypertension in judokas from Perm

To adjust the training process, it is important to know the predisposition of martial artists to the development of physical qualities, as well as the predisposition to the development of cardiovascular diseases, such as arterial hypertension. The purpose of this research is to study the relationship between the CYP11B2 gene polymorphism (cytochrome P450, family 11, subfamily B, polypeptide 2) and the development of arterial hypertension in judokas of the «Vityaz school» in Perm. The research sample included 147 people divided into two groups: Group I, including martial artists with normal blood pressure, and Group II, which consisted of athletes with arterial hypertension. In subjects aged 10 to 16 years, studies were conducted using real-time polymerase chain reaction (RT-PCR) and T/C polymorphism of the CYP11B2 gene (rs1799998) was detected. Spearman correlation analysis revealed a positive relationship (rs=0.597) between the T/T genotype values of the CYP11B2 gene in the subjects and the presence of arterial hypertension. Genetic analysis data are necessary in the process of training martial artists in sports schools, since they can be used to create individual training programs taking into account the genotype and physical fitness characteristics of a particular athlete.