Молекулярные маркеры чувствительности и резистентности карцином толстой кишки к терапии антагонистами EGFR

Автор: Иванцов А.О., Янус Г.А., Суспицын Е.Н., Анисимова Е.Н., Имянитов Е.Н.

Журнал: Сибирский онкологический журнал @siboncoj

Статья в выпуске: 1 (73), 2016 года.

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Таргетная терапия метастатического рака толстой кишки отличается отсутствием молекулярных маркеров, позволяющих предсказать наличие выраженной чувствительности к специфическому ле- чению. Вместе с тем для анти-EGFR антител известны надежные маркеры резистентности к терапии. Их определение стало обязательной процедурой, предшествующей назначению соответствующих лекарственных препаратов. «Золотым стандартом» сегодняшнего дня, обозначенным в различных клинических рекомендациях, является анализ всей кодирующей последовательности генов KRAS и NRAS в опухолевой ткани. Мутации в KRAS и NRAS встречаются в 45-65 % карцином толстой кишки. Тем не менее исключение пациентов, в чьих опухолях были обнаружены мутации KRAS и NRAS, не решает полностью проблему отбора больных. Это стимулирует поиск новых предиктивных маркеров. К настоящему моменту практически доказана предиктивная роль мутаций V600E в гене BRAF. Интенсивно изучается роль мутаций и/или нарушений экспрессии генов PIK3CA, PTEN, EREG, AREG, IGF2, а также амплификаций HER2/neu и MET. Ожидается, что работы в данном направлении позволят существенно повысить клиническую и экономическую эффективность лечения рака толстой кишки.

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Аденокарцинома, рак толстой кишки, анти-egfr антитела, предиктивные маркеры

Короткий адрес: https://sciup.org/14056786

IDR: 14056786 | DOI: 10.21294/1814-4861-2016-15-1-59-66

Список литературы Молекулярные маркеры чувствительности и резистентности карцином толстой кишки к терапии антагонистами EGFR

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