Молекулярные основы современных подходов к анализу продуктивной функции тимуса

Автор: Сайдакова Е.В.

Журнал: Вестник Пермского университета. Серия: Биология @vestnik-psu-bio

Статья в выпуске: 2, 2015 года.

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Рассмотрена информация о тимусе - центральном органе иммунной системы, обеспечивающем микроокружение, необходимое для созревания и селекции CD4+ и CD8+ Т-лимфоцитов. Дана справка об основных событиях в истории изучения вилочковой железы. Продемонстрирована высокая значимость органа в восстановлении иммунной системы при опустошении пула Т-лимфоцитов. Представлены данные о молекулярных механизмах формирования разнообразия антигенраспознающих рецепторов Т-клеток, которые легли в основу современных подходов к анализу продуктивной функции вилочковой железы. Приведены примеры использования методов определения функциональной активности тимуса в науке и клинической практике.

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Тимус, т-клеточный рецептор, реаранжировка сегментов генов, пцр

Короткий адрес: https://sciup.org/147204723

IDR: 147204723

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