Morpho-functional evaluation of enzymatic and detergent decellularization methods of cardiac allografts

In this study we conducted a comparative analysis of enzyme and detergent methods of decellurizing cardiac allografts. It was shown that by using the detergent method, the highest degree of purification of the valve from the cells could be achieved, while preserving its original mechanical strength and the spatial structure of its matrix. Based on these data, the detergent method can be recommended as a preferred choice during preparation of allografts for use in cardiac surgery practice.