Morphofunctional condition of the liver when using nanostructured sapropel for example white mouse

The nanostructured sapropel consists of polygonal particles with a size of 50.0-180.0 nm, stabilized by electrostatically deionized water. The effect on the morphofunctional state of the liver of white mice with intragastric administration of lethal, toxic and safe doses was studied. With a single dose of a lethal dose of 3,0 g/kg, the autopsy picture showed acute toxic poisoning, the liver was enlarged in volume, the capsule was tense, and single point hemorrhages under the capsule. Histologically, the liver revealed the plethora of capillaries, the destruction of individual centrolobular hepatocytes, and focal necrosis. When a toxic dose of 1,8 g/kg was administered, the liver was enlarged, the intensity of the capsule was observed, and the pattern characteristic of the organ dystrophy was observed. Microscopically revealed the safety of the beam structure, moderate plethora of capillaries, single centrolobular hepatocytes with karyolysis. With the introduction of a safe dose of 0,6 g/kg, no visual changes in the liver have been established. Histologically, the structure of the organ and cells was unaffected and corresponded to the physiological norm.