Morphological structure of hemato-neuronal and hemato-cerebral barrier tissues in cattle fetuses with chlamydial infection

Chlamydial infection in fetuses is accompanied by the development of intrauterine hypotrophy, indicating a damage to the fetoplacental barrier. A characteristic pathological and anatomical feature is the formation of widespread edema, both tissue and cavitary localization. Histological examination in organs and tissues shows changes in the pathological character developing at the level of the vascular bed, alterative processes, immunopathological reactions, systemic inflammatory changes in the hemato-liquor and hemato-neuronal barriers. Changes in the hemato-neuronal barrier were characterized by the appearance of neurocytes with pycnotic or optically transparent nuclei, decay of the tiger substance in unipolar and bipolar neurons, vacuolization or granularity of the cytoplasm, fuzzy contours of their cell walls, and the appearance of nuclear-free cells, which indicates the death of cells in which dystrophic, necrobiotic and necrotic changes. The pathological process also affected the elements of glia: astrocytes (small cells with a large nucleus and an indistinctly expressed area of the cytoplasm) increased in size, their cytoplasm became clearly visible and acquired a granular appearance...