Pathological changes in the wall of the vein adapted to arterial circulation

The aim of the study is evaluation and comparison of pathomorphological changes in vein wall adapted to arterial circulation with patients after autogenous femoral-popliteal bypass using the "in situ” and reversed vein technique, as well as arterialization of the superficial foot vein. The material for this study was parts of arterialized venous (n = 7) wall obtained during repeated surgery. Micropreparations studied by histological (stain hematoxylin and eosin, orcein and according to Mallory) and immunohistochemical (Ki-67, CD31, a-SMA) methods. The identified pathomorphological changes in vein wall adapted to arterial circulation are characteristic of nonadaptive remodeling of the venous wall and include its thickening, endothelial damage with the formation of a mosaic monolayer and its proliferation, neointimal fibrous and smooth muscle hyperplasia as a result of migration and proliferation of leiomyocytes and increase in collagen production, remodeling of the connective tissue matrix and inflammatory infiltration.