Morhological changes of myenteric ganglia in experimental acute ulcerative colitis

Myenteric ganglia of colon of C57Bl/6 mice with acute DSS-induced colitis were investigated. The cell composition of myenteric ganglia and cytometric values of myenteric neurons were studied. It was found a decrease in number of hypochromic neurons and glial cells and an increase in number of hyperchromic neurons. The area of neurons and their nuclei decreased in colitis. These morphological changes of myenteric ganglia in colitis may cause an impairing of motor and secretory functions of colon.