Morphological features of the lymphoid tissue and microvessels in regional lymph nodes in gastric cancer

The morphological features of lymphoid tissue and microvessels in samples of regional lymph nodes without metastases were studied in 44 patients with gastric cancer. The samples were stained with hematoxylin-eosin and immunohistochemically using antibodies to CD34. In lymph nodes identified the following types of microvessels: the usual microvessels, the dilated capillaries and the atypical capillaries that were formed by the cells with the phenotype of the blast. Presence of abnormal capillary endothelial cells of blast phenotype was associated with the degree of differentiation of gastric cancer, the type of tumor growth and the amount of lymph follicles to the border of the tumor and gastric mucosa. Also, positive correlation with the area of the square of germinal centers of lymph follicles, an area of germinal centers, the size of the of lymph follicles, with the number of lymph follicles on the border of the gastric mucosa and tumors and the presence of dilated capillaries in the gastric submucosa and negative - a density of lymph follicles and microvessel density in them...