Morphological transformations in rats Ca2 and Ca4 hippocampa of rats at modeling of chronic alcohol intoxication and pharmacological correction by succicard and citrocard compounds

A quantitative analysis of pathomorphological transformations in the pyramidal layer of the CA2 and CA4 zones of the hippocampus of rats was performed in the modeling of chronic alcohol intoxication and pharmacological correction with Succicard and Citrocard compounds. In rats receiving the studied compounds, a tendency was identified for the reverse development of compensatory-adaptive and neurodegenerative processes in the pyramidal layer of the hippocampal zones CA2 and CA4, which were caused by forced alcoholization, which in turn confirms the pronounced neuroprotective effect of the studied compounds and the presence of different degrees of severity of the action of these substances, the prevalence of efficacy is observed in the compound Citrocard, the most pronounced changes were observed mainly in the CA2 zone by morphometric studies, which in turn emphasizes the importance of the study of drugs of natural metabolites of the nervous system and their analogues.