Morphological reaction of the labyrinth zone of the white rats placenta at the parenteral injection of gold nanoparticles of different sizes

Nanoscale materials are increasingly used to solve the fundamental problems and in applied biomedical research. The most well studied toxicity, biodistribution and biophysical properties of gold nanoparticles. They occupy a special place among the nanoscale materials used for diagnostic and therapeutic purposes, actively investigated as a nanosized tools for optical or magnetic imaging of cells and tissues, as carriers how of medicinal products for human and animal diagnostic preparations of the new generation. In the making of new drugs, the study of placental permeability barrier for them, as a rule, limited to the parameters of the general and selective toxicity study cellular responses mother and fetus, the nearest and distant teratogenicity. Nanotechnology can offer to solve the problem with more informative methods associated with drug conjugates. Nanopharmaceutics drugs can help in studies of mechanisms not only of placental permeability, but also of other blood-tissue barriers...