Morphological study of human U-87 MG glioblastoma subcutaneous xenografts after local irradiation by epithermal neutrons

Currently, boron neutron capture therapy is increasingly used to treat malignant tumors. This method is effective against radioresistant tumors and neoplasms that are poorly amenable to traditional treatment methods, but the issue of increasing its effectiveness remains highly relevant. The aim of the study was to study the structure of subcutaneous xenografts of human glioblastoma U-87 MG after local irradiation with epithermal neutrons and/or against the background of treatment with boron-containing substances - borocaptate and boron phenylalanine. Sixty immunodeficient SCID mice with heterotopic xenografts of human glioblastoma U-87 MG cells were used. It was found that after the therapy in all groups of animals by the 7th day there was a decrease in the tumor mass compared to the control group, by the 14th day this indicator was also slightly lower and only the combined administration of borocaptate and boronophenylalanine followed by irradiation led to a reliable decrease in this indicator by 31% (p