Морфологическое исследование подкожных ксенографтов глиобластомы человека U-87 MG после локального облучения эпитепловыми нейтронами

Автор: Каныгин В.В., Колдышева Е.В., Завьялов Е.Л., Соловьева О.И., Каныгин Н.В., Капустина В.И.

Журнал: Морфологические ведомости @morpholetter

Статья в выпуске: 1 т.32, 2024 года.

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В настоящее время для лечения злокачественных опухолей все чаще используется бор-нейтронозахватная терапия. Этот метод эффективен в отношении радиорезистентных опухолей и новообразований, плохо поддающихся традиционным методам лечения, однако вопрос повышения его результативности остается высоко актуальным. Цель исследования - изучить структуру подкожных ксенографтов глиобластомы человека U-87 MG после локального облучения эпитепловыми нейтронами и/или на фоне введения борсодержащих веществ боркаптата и борфенилаланина. Использовали 60 иммунодефицитных мышей линии SCID с гетеротопическими ксенографтами клеток глиобластомы человека U-87 MG. Установлено, что после проведенной терапии во всех группах животных к 7-м суткам наблюдалось снижение массы опухоли по сравнению с контрольной группой, к 14 суткам этот показатель был также несколько ниже и только сочетанное введение боркаптата и борфенилаланина с последующим облучением приводило к достоверному снижению этого показателя на 31% (p

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Глиобластома, ксенографт, борфенилаланин, боркаптат, эпитепловые нейтроны

Короткий адрес: https://sciup.org/143183610

IDR: 143183610 | DOI: 10.20340/mv-mn.2024.32(1).856

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