The morphology of the liver of rabbits with experimentally induced hepatitis and its correction by means of metabolic action

The purpose of these studies was to study the pathology of experimental hepatitis in rabbits after intraperitoneal exposure to carbon tetrachloride, and before and after the use of the drug "Yantovet". The active ingredient of the drug is succinic acid, which has a direct modifying effect on cellular metabolism, in which there is an activation of aerobic glycolysis under hypoxic conditions and an organic phosphorus compound, which potentially enhances the synthesis of macroergic molecules. At the end of the study, animals were euthanized in a CO2 chamber. Аthological examination included necropsy and histological techniques. In animals of the first group, which were injected with carbon tetrachloride, the pattern of the histological structure of the liver was mild. Rabbits of the second group had a liver, the radial direction of the hepatic beams in which was violated, in places they were interrupted due to the complete destruction of the hepatocytes. The suppression of the biosynthetic activity of the organ parenchyma cells in these animals was combined with a sharp decrease in the number of cells with two nuclei...