The morphology of the duodenal mucosa, contaminated by campylobacter, cryptosporidium and fungi of species Candida in patients with irritable bowel syndrome

Irritable bowel syndrome is a certain spectrum of functional gastrointestinal tract disturbances. However recent data indicate, that patients with the mentioned syndrome present with noticeable morphological changes in the gastrointestinal tract mucosa. The aim of the study was evaluation of morphological changes in the duodenal mucosa in the course of its contamination with Campylobacter, Candida and Cryptosporidium in patients with irritable bowel syndrome. Patients under 50 years old (14 women and 10 men) with irritable bowel syndrome underwent complex clinical, laboratory and instrumental examination including esophagogastroduodenoscopy and colonoscopy with biopsy. Histological examination of bioptates, obtained from the patients' duodenal mucosa, revealed various grades of chronic duodenitis accompanied by high density of inflammatory cellular infiltrate (which consisted of plasmocytes, lymphocytes, macrophages, fibroblasts and fibrocytes), by duodenal villous atrophy, by low count of Paneth cells or their absence, by Brunner's glands' hyperplasia, by presence of Campylobacter, Candida and Cryptosporidium in the duodenal mucosa. The revealed duodenal mucosa morphological changes indicated on chronic inflammation accompanied with gut biocenosis abnormalities.