Morphometric features of the spleen of rats during the period of presenile changes under the influence of xenogeneic cerebrospinal fluid

The article describes the structure features of spleen of presenile period rat in normal and after xenogeneic cerebrospinal fluid administration. The saline or liquor was injected intramuscularly three or ten times each 3 days in a doze 2 ml/kg. In presenile period marked changes the decrease of immune defense are observed. That proved by decline white pulp of the spleen, vanish of the lymph nodes, disappearance of the germinal centers. Three time injections of the cerebrospinal fluid caused some inhibition of degradation processes: more lymph nodes with germinal center of the lymphocytes are appeared; the edge of the zones of lymph nodes was precise. Ten time injection had slight effect on white pulp of the spleen. Significantly reduced the number of active centers of the lymph nodules with breeding zone, border of areas nodules are erased.