Morphometric analysis of diffuse endocrine systems components in esophagogastroduodenal zone in different periods after cholecystectomy

The examination of morphofunctional features of esophagus, stomach, and duodenum as well as the role of diffusive endocrine systems cells in development of esophagogastroduodenal zone in patients without gallbladder is the purpose of the study. 80 patients with various periods after cholecystectomy and 72 patients with cholelithiasis were examined. Endoscopic, histological and immuno-histochemical studies were carried out against all examined patients. The amount of epitheliocytes producing motilin (EC 2), glucagon (L), and pancreatic polypeptide (РР) in duodenum were determined using antibodies sets. Esophagitis, atrophic- and reflux-gastritis, duodenal reflux are positively rather frequently met, atrophy and dysplasia of gastric mucous membrane increase in patients without gallbladder during the time after cholecystectomy. Hypoplasia of epithelial cells producing motilin, glucagon and pancreatic polipetide progresses. The development of duodenal and gastroesophagial reflux is associated with hypoplasia of epithelicytes producing motilin; the development of erosive changes is connected with hypoplasia of L and PP cells; the development of atrophic changes is closely related with hypoplasia of all studied cell types. The decrease of hormone producing epythelicytes promotes initiation and persistence of morphofunctional changes in esophagogastricduodenal zone. And this in turn can serve as additional diagnostic and prognostic criterion.