Mutations in TP53 supressor gene and their association with breast cancer
Автор: Denisov E.V., Litvyakov N.V., Stakheeva M.N., Garbukov E.Yu., Slonimskaya E.M., Malinovskaya E.A., Babyshkina N.N., Stegniy V.N., Cherdyntseva N.V.
Журнал: Сибирский онкологический журнал @siboncoj
Рубрика: Лекции
Статья в выпуске: 2 (26), 2008 года.
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The frequency of TP53 supressor gene mutations at exons 5,7 and 8 in tumor tissue of 60 patients with breast cancer was assessed using PCR-SSCP-analysis. The frequency of mutations was 61.7% (37/60) that was in accordance with literature data. High frequency of multiple mutations of TP53 gene and association of mutations at exon 5 with metastatic involvement of regional lymph nodes were shown.
Breast cancer, tp53 oncosupressor gene, mutations, prognosis
Короткий адрес: https://sciup.org/14054840
IDR: 14054840
